This minor variant is now known as “self‐improving collodion ichthyosis.”28 The group of Hotz et al. studied a cohort of 770 families with a clinical diagnosis of ARCI and identified pathogenic variants in 54 families,29 which expanded the known clinical and molecular spectrum of patients with ARCI due to CYP4F22 variants. Here, CYP4F22 is linked to autosomal recessive congenital ichthyosis.