ILC2 primarily reside in the mucosal barrier, mesenteric lymph nodes, spleen, and peripheral blood, mediating the mutual promotion between innate immunity and adaptive immunity.8–10 Like Th2 cells, ILC2 express GATA-3 and secretes type 2 cytokines in response to IL-25, IL-33, and Thymic Stromal Lymphopoietin (TSLP).9,11 In the early stage of infection, ILC2 have been activated while adaptive immunity has not yet been established. Here, IL33 is linked to infection.