RPS6KB1 and neoplasm: It interacts with phosphodiesterase 3B (PDE3B) to regulate lipolysis and is thought to suppress tumor growth by inhibiting the expression of ribosomal protein S6 kinase beta-1 (S6K1) and downstream glycolysis-related molecules, including Glucose transporter 1 (GLUT1), pyruvate kinase M2 (PKM2), and lactate dehydrogenase A (LDHA) [106, 107].