Specifically, the downregulation of FDX1, DLAT, SDHB (succinate dehydrogenase complex, subunit B), and DLST (dihydrolipoamide S-succinyltransferase) genes in primary CRC tissues suggests a link to disease progression, with higher expression of these genes correlating to better prognosis [195–198]. Here, DLST is linked to colorectal carcinoma.