CDKN2A and head and neck squamous cell carcinoma: The cuproptosis-related gene Cyclin-dependent kinase inhibitor 2A (CDKN2A) is linked to the malignancy of head and neck squamous cell carcinoma (HNSCC), with plicamycin showing strong binding to CDKN2A and inhibiting HNSCC progression, indicating its role as a cuproptosis inducer [202].