To explore host directed therapy for an important mechanism of HIV pathogenesis, we treated HIS mice with rFLT-3 L and subsequently infected all animals with HIV as illustrated in Fig. 3A. As shown in Fig. 3B, a marked decrease in the percentage and number of peripheral blood CD45+ cells was detected by flow cytometry at 14 days post-infection with HIV compared to the day 0 pre-infection measurements of the same animal. Here, PTPRC is linked to infection.