Specifically, ERRγ modulates the activity of genes associated with energy metabolism, PANX2 (controls glucose tolerance and apoptosis), LGR6 (a key component of HCC survival), and CNPase (a gene that could have a crucial role in upholding mitochondrial function and averting mitochondrial malfunction) (Fig. 1L, Table S5). Here, LGR6 is linked to hepatocellular carcinoma.