Typically, DHB12 and FADS1 (fatty acid metabolism), FABP7 and FADS1 (PPAR signaling pathway), DHB12 (fatty acid elongation), AKT3 (glucagon signaling pathway and insulin resistance), CP7A1 (Fig. 3N), E2F1 (NAFLD disease) (Fig. 3O), MIXIP (HCC disease) (Fig. 3P) G6PI (Fig. 3Q) and LDHA (glycolysis/gluconeogenesis) shown more PEIs and were regulated by the SE or RE in goose HFD tissues (Table S8). The gene discussed is E2F1; the disease is Insulin resistance.