Among the 126 genes implicated in NAFLD (ko04932), 23 genes demonstrated significant RPS modifications between the compared groups, including the key genes BID, IGF1R, and INS. These findings indicate potential regulatory functions for the genes involved in immunity, HCC, and NAFLD, underscoring their putative roles in the intricate processes governing these biological phenomena. This evidence concerns the gene IGF1R and metabolic dysfunction-associated steatotic liver disease.