In a disseminated, syngeneic RM9-hSTEAP1 tumor model in hSTEAP1-KI mice, STEAP1 CAR T cells combined with a collagen binding domain IL-12 enhanced OS, cytokine production, tumor antigen presentation, and dissemination with epitopes to prevent STEAP1 antigen escape [192]. The gene discussed is STEAP1; the disease is neoplasm.