Several factors have been identified as potential risk factors for HBV and HIV co-infection, including socio-demographic factors such as age, sex, monthly income, educational level, marital status, place of residence, current occupational status, health-related factors such as history of blood transfusion, multiple sexual partner, CD4 count, surgical history, OIs, history of hospital admission, history of STDs/STIs, viral load status, cultural factors such as tattoo on the body, ear piercing, and tooth extraction, and behavioral factors such as smoking and alcohol drinking [6–8]. This evidence concerns the gene CD4 and sexually transmitted disease.