Start within the multiple logistic regressions namely sex, educational status, viral load, marital status surgical history, and CD4 count) were significantly associated with HIV-HBV co-infection, then The analysis revealed that females were 0.14 times less likely to be infected with HBV co-infection compared to males, with an 86% reduction in the odds of HBV infection [AOR = 0.14; 95% CI: 0.041, 0.478]. The gene discussed is CD4; the disease is coinfection.