The main evidence for this hypothesis is that neurons of the AD brain showed cyclin B1, cyclin D1, cdc2, and Ki67 phospho-protein expression which are normally identified during mitosis (Arendt 2012; McShea et al. 1997; Vincent et al. 1997, 1996; Yang et al. 2001). This evidence concerns the gene MKI67 and Alzheimer disease.