Bioinformatics showed that miR-3614-5p could be absorbed by LOXL1-AS1 sponge, while Yin Yang 1 (YY1) was confirmed to be the target gene of miR-3614-5p, and YY1 deletion could inhibit the malignant behavior of HCC cells. The gene discussed is PTGDR; the disease is hepatocellular carcinoma.