HK2 and cancer: It has been reported that miR-21 [37], miR-761 [48] and miR-324-3p [65] is involved in the carcinogenic activity of LOXL1-AS1, but its downstream targets and their signal pathways or biomolecule interactions need to be further studied. Abnormal expression of hexokinase (HKs) is a feature of glycolysis in cancer cells, while HKs (mainly HK2) is overexpressed in many cancers.