In addition, the higher the expression level of LOXL1-AS1, the later the TNM stage of EC [17], CRC [22], CC [53], BC [55], CCA [65] and ESCC [70], and most of them were accompanied with lymph node metastasis, indicating the poor prognosis. The gene discussed is LOXL1; the disease is esophageal squamous cell carcinoma.