CXCL8 and neoplasm: In the present study, we showed that: (1) palbociclib makes tumor cells senescent with a reversible phenotype; (2) the senescent phenotype induced by palbociclib is endowed with an inflammatory secretome that can recruit and activate neutrophils through the release of different inflammatory factors, such as IL-8 and SAA1; (3) the activated neutrophils are able to perform phagocytic removal of senescent tumor cells.