At this time, a group of angiogenesis-related TAMs required for tumor angiogenesis, also known as monocyte/macrophages (TEMs) expressing TIE2, showed a serious M2 deflection phenotype, characterized by increased expression of MRC1 and CD163, while the expression levels of MHCII molecules and pro-inflammatory cytokines were relatively low [128]. The gene discussed is MRC1; the disease is neoplasm.