IFI16 and heart disorder: This review delves into the emerging understanding of the potential role of IFI16 in heart diseases, with a specific focus on its intricate relationship with PANoptosis – a newly recognized form of pro-inflammatory programmed cell death encompassing the simultaneous activation of pyroptosis, apoptosis, and/or necroptosis, but that cannot be accounted for by any of these three programmed cell death pathways alone [9–11].