For example, in pancreatic islets exposed to IL-1β, Gal3 is the most upregulated protein, and its overexpression protects β cells from the cytotoxic effect of IL-1β39, transgenic overexpression of Gal3 in pancreatic β cells was found to protect β cells from apoptosis in T1DM mice40. This evidence concerns the gene LGALS3 and type 1 diabetes mellitus.