Given that CD47 seems to be predominantly expressed in FoxJ1+ cells (deuterosomal cells and, to a lesser extent, multi-ciliated cells) based on single-cell RNA sequencing and immunostaining analysis of upper and lower airway primary epithelial cells, we initiated an investigation into the involvement of CD47 in secondary bacterial infections using a FoxJ1+ cell-specific CD47 gene-deletion mouse model and CD47 neutralizing antibodies. Here, FOXJ1 is linked to bacterial infectious disease.