We found that the proliferation and colony formation functions of MLL-r AML cells were suppressed significantly upon loss of EP300 or CREBBP (Fig. 2B, C), while, the proliferation of the MLL wild-type cells was less influenced, highlighting a specific vulnerability of MLL-r leukemia to EP300/CREBBP depletion (Additional file 1: Fig. S2B). This evidence concerns the gene KMT2A and acute myeloid leukemia.