Although ATAC-seq results demonstrated that EP300/CREBBP had a critical role in MLL-r AML development, the expression of EP300/CREBBP were upregulated in MLL-r cells as well as in AML cells with other genetic mutations (Additional file 1: Fig. S1C), suggesting EP300/CREBBP function were not close to their expression. Here, CREBBP is linked to acute myeloid leukemia.