The enrichment of H3K27Ac were reduced at the promoter regions of E2F1, E2F3, MCM2, MCM3 and MCM4 in MLL-r AML cells after A-485 treatment, but the modification of H3K27Ac remained unaltered in MLL wild-type AML cells, (Fig. 5C, Additional file 1: Fig. S6C). Here, KMT2A is linked to acute myeloid leukemia.