Since germline null Glis2−∕− mice develop progressive nephronophthisis-like chronic kidney disease that is evident at 4 months age50, we developed an inducible conditional Glis2fl/fl; Pkd1fl/fl; Pax8rtTA; TetOCre model to evaluate the effects of contemporaneous Glis2 inactivation on cyst growth in later onset mouse models. This evidence concerns the gene GLIS2 and chronic kidney disease.