Since germline null Glis2−∕− mice develop progressive nephronophthisis-like chronic kidney disease that is evident at 4 months age50, we developed an inducible conditional Glis2fl/fl; Pkd1fl/fl; Pax8rtTA; TetOCre model to evaluate the effects of contemporaneous Glis2 inactivation on cyst growth in later onset mouse models. Here, GLIS2 is linked to cyst.