We used two previously established ALS/FTD Xenopus laevis (X. laevis) models (Murakami et al., 2015; Qamar et al., 2018): the ALS-associated NLS mutant FUS(P525L), a common cause of juvenile ALS (Picher-Martel et al., 2020), and an artificial mimic of hypomethylated FUS, FUS(16R), which contains 16 strategically inserted arginine residues to increase the protein's overall hypomethylation state (Qamar et al., 2018). Here, FUS is linked to amyotrophic lateral sclerosis.