ALS and FTD have also been linked to mutations in cytoskeleton-associated genes, including in α-tubulin 4A (Smith et al., 2014; Mol et al., 2021), Spastin (Meyer et al., 2005; Münch et al., 2008), dynactin subunit-1 (Puls et al., 2003; Münch et al., 2004, 2005), kinesin family member 5A (KIF5A; Nicolas et al., 2018; Saez-Atienzar et al., 2020), Profilin-1 (PFN1; Wu et al., 2012), and Alsin (Hadano et al., 2001; Yang et al., 2001). Here, SPAST is linked to frontotemporal dementia.