Whereas DNAm CRP was strongly associated with history of cardiovascular disease (odds ratio [OR] = 1.28, pFDR = 6.6 × 10−3), hypertension (OR = 1.30, pFDR = 2.3 × 10−3), stroke (OR = 1.63, pFDR = 3.4 × 10−3), and type 2 diabetes (OR = 1.72, pFDR = 8.0 × 10−5), assay-measured CRP was weakly associated only with hypertension (OR = 1.19, pFDR = 0.03) and stroke (OR = 1.41, pFDR = 0.03). This evidence concerns the gene CRP and hypertensive disorder.