Cox regression analysis showed that age, glioma grade, ve_90, vp_skew, PDZK1, vp_kurt, and kep_90, were significant predictors of OS, and age, Glioma grade, ve_90, ve_skew, and PDZK1 were predictive indicators for PFS (Table 3). The gene discussed is PDZK1; the disease is central nervous system cancer.