In the DCM subcohort, 93 index cases were genetically analyzed, identifying a total of 185 genetic variants in 85 of them: 99 in genes with a definitive clinical validity to DCM (DES, DMD, FKTN, FLNC, LAMP2, LMNA, MYH7, RBM20, SCN5A, TNNT2 and TTN), 6 in a gene with strong clinical validity (DSP), 14 in genes with a moderate clinical validity (ACTC1, ACTN2, JPH2, NEXN, TNNI3 and VCL), 21 in genes with limited clinical validity and 45 in genes with a disputed/refuted association or no association to DCM. Here, ACTN2 is linked to familial dilated cardiomyopathy.