The m6A epitranscriptome plays a critical role in regulating the expression of genes that promote oncogenic growth in many types of adult cancers, although little is known about its function in pediatric cancers.7 In this study, we show that high levels of METTL3 and METTL14 in neuroblastoma are associated with aggressive tumor growth and poor survival. Here, METTL3 is linked to neuroblastoma.