METTL3 and neoplasm: Similar to other pediatric cancers, there is a paucity of recurrent genomic mutations in neuroblastoma, and epigenetic dysregulation plays a key role in determining neuroblastoma phenotype and cell lineage.14–16 Neuroblastoma cells classically exhibit plasticity between adrenergic and mesenchymal lineages, and recent reports show that both populations are present in neuroblastoma tumors.14,17 In this study, we investigated the effects of METTL3-dependent m6A RNA modifications on neuroblastoma gene expression and tumor growth.