HAND2 and neuroblastoma: The list included genes expressed in chromaffin cells in the mature adrenal gland (CHGA, CHRNA3), genes that mediate retinoic-acid-induced neuroblastoma differentiation (SOX4, HAND2, TBX2, TBX3),14,29 and genes that are up-regulated in differentiated neuroblastoma cells (NTRK1, HOXC9).24,29,30 Increased expression scores of a subset of these genes, such as TBX3, CHRNA7, and FN1, was shared among NGP and SK-N-BE2 cells treated with STM2457 (Table S2).