Our results also showed that the expression of IL4I1 in CESC, COAD, ESCA, HNSC, KIRP, LGG, LIHC, GBM, LUAD, pheochromocytoma and paraganglioma, READ, sarcoma, STAD, and testicular germ cell tumors was negatively correlated with tumor purity and positively correlated with the degree of TAM invasion (Fig. 5B). Here, IL4I1 is linked to hereditary pheochromocytoma-paraganglioma.