SNCA and neurodegenerative disease: The potential relevance of nhr-210 was substantiated by our observations that nhr-210 knockdown in C. elegans alpha-synuclein expressing models (NL5901 expresses alpha synuclein in muscles and UA44 expresses alpha synuclein specifically in dopaminergic neurons) reduced α-synuclein aggregation, a hallmark of several neurodegenerative diseases [46], 47, alongside global ROS levels and influenced behavioral functions.