TMPRSS3 and hearing loss disorder: Although TMPRSS3 has been shown to activate epithelial sodium channels (ENaC) (Guipponi et al. 2002) and impact the level of the calcium-activated potassium (BK) channel KCNMA1 (Molina et al. 2013; Tang et al. 2019), the exact role of TMPRSS3 in hearing—and by association in hearing loss—is poorly understood.