NR3C2 and Increased circulating aldosterone concentration: Apparent mineralocorticoid excess (AME) Apparent mineralocorticoid excess (AME) is a recessive disorder caused by a congenital defect of the renal in 11-beta-hydroxysteroid dehydrogenase type II (HSD11B2) isozyme, which normally metabolizes cortisol to cortisone and prevents cortisol from binding to the mineralocorticoid receptor.