MTHFR and hereditary thrombophilia due to congenital protein S deficiency: Relevant maternal medical conditions included 22 (16%) cases with an underlying thrombophilic conditions (history of DVT, genetic mutations such as MTHFR, FVL and protein S deficiency, APLA syndrome), 9 (7%) hypertensive disorders (chronic hypertension, gestational hypertension, or preeclampsia).