In high-grade serous ovarian carcinoma (HGS-OvC), ANKLE2 is part of a network of 12 genes that interact with VIRMA, an RNA methylation/adenylation gene that contributes to tumor aggressiveness through N6-methylation of adenosine (m6A), ultimately targeting RNA as their ultimate destination (Miranda-Gonçalves et al., 2021). The gene discussed is ANKLE2; the disease is neoplasm.