APOB and diabetes mellitus: These factors encompassed a history of HTN or blood pressure of 140/90 mm Hg or higher, regular physical activity, Apo B/Apo A1 ratio, dietary patterns, waist-to-hip ratio, psychosocial factors, current smoking, cardiac causes, alcohol consumption, and diabetes mellitus.7 Lastly, the prospective cohort study known as PURE reported HTN as the most significant risk factor for CVD.