APOB and diabetes mellitus: First, the INTERHEART study suggested current smoking and raised apolipoprotein (Apo) B/Apo A1 ratio as the two strongest risk factors for myocardial infarction, followed by a history of diabetes, HTN, and psychosocial factors.6 Furthermore, the INTERSTROKE study identified 10 potentially modifiable and prevalent risk factors that accounted for 90% of the population attributable risk for stroke.