IFNA1 and lymphopenia: Several hallmarks of severe COVID-19 have been identified, including overproduction of proinflammatory cytokines (7–9), lymphopenia (7, 10, 11), formation of neutrophil extracellular traps (NETs) (12), impaired IFN signaling (13–16), presence of anti-IFN autoantibodies (17), and immune senescence (18).