FH and age-related macular degeneration: The Y402H polymorphism is present in both FH and FHL-1, but it likely predominantly exerts its effect on AMD pathogenesis through FHL-1, as FHL-1 has been demonstrated to be the major complement regulator of BM; its truncated form allows it to passively diffuse through BM, while FH is located in the ECM of the choroid (83, 84).