Of note, faster cross-bridge detachment accompanied by hypercontractility caused by a higher number of myosin heads in the disordered relaxed (DRX) state have been reported for the β-MYH7 mutations R403Q and P710R, which cause hypertrophic cardiomyopathy (HCM) (34–36). This evidence concerns the gene MYH14 and hypertrophic cardiomyopathy.