AGT and hypertensive disorder: Preclinical data now support that AGT siRNA lowers blood pressure and exerts cardio- and renoprotection in a variety of animal models with hypertension and chronic kidney damage.4,10–12 Interestingly, these studies simultaneously showed that Ang (angiotensin) generation in the heart, brain, adipose tissue, and kidney relied on hepatic AGT and that the massive renin rises accompanying near-complete (>99%) AGT lowering tended to further consume any remaining AGT, resulting in the virtual disappearance of Ang II (angiotensin II).