RVHD: rheumatic valvular heart disease; CAD: coronary artery disease; OR: Odds ratio -Exp (β), CI: confidence interval; WBC: white blood count; NLR: neutrophil to lymphocyte ratio; ALT: alanine aminotransferase; AST: aspartate aminotransferase; ALP: alkaline phosphatase; GGT: gamma-glutamyl transferase; PT: prothrombin time; PTT: partial thromboplastin time; INR: international normalized ratio; BUN: blood urea nitrogen; TC: total cholesterol; LDL: low-density lipoprotein. The gene discussed is F2; the disease is coronary artery disorder.