RVHD and non-RVHD; rheumatic and non-rheumatic valvular heart disease, CAD; coronary artery disease, WBC: white blood cell count; NLR: neutrophil to lymphocyte ratio; ALT: alanine aminotransferase; AST: aspartate aminotransferase; ALP: alkaline phosphatase; GGT: gamma-glutamyl transferase; PT: prothrombin time; PTT: partial thromboplastin time; INR: international normalized ratio; BUN: blood urea nitrogen; TC: total cholesterol; LDL: low-density lipoprotein; HDL: high-density lipoprotein; TG: triglyceride. The gene discussed is F2; the disease is coronary artery disorder.