showcased that such a combined treatment reduced inflammation and cellular damage markers, improved NO, and vascular endothelial growth factor (VEGF) levels, alongside an increased SIRT1 expression, indicating a synergistic role in alleviating sepsis-induced inflammation, cellular damage, and oxidative stress - an assertion confirmed through histopathological analyses of the heart and kidneys (159). This evidence concerns the gene SIRT1 and Sepsis.