IL4 and helminthiasis: Conversely, the Th2 phenotype, regulated by GATA-binding protein 3 (GATA3) and induced by IL-4, orchestrates responses against extracellular pathogens, orchestrating effector cytokines like IL-4, IL-5, IL-9, and IL-13 (20, 21), while recruiting eosinophils, basophils, and mast cells, significant cells in helminth infections and allergic reactions (22–24).