IL-17A, a crucial cytokine in the disease pathogenesis, has been shown to stimulate autophagosome formation in early stages; however, upon longer-term exposure to IL-17A in keratinocytes, it inhibits autophagy through the activation of the PI3K/AKT/mTOR signaling pathway, indicating a dynamic crosstalk between autophagy and inflammation in psoriasis (78). This evidence concerns the gene IL17A and psoriasis.