To assess whether the anti-tumour activity of FIH KO T cells was a restricted or more general feature, we carried out in vivo experiments using an adoptive transfer model, with MHC-I restricted OT-I T cells transferred into B16 tumour-bearing mice, as well as an orthotopic B16 tumour model using wild-type or T cell-specific FIH knockout mice. Here, CASR is linked to neoplasm.