In view of the above causes, the therapeutic targets of AD mainly include acetylcholinesterase (AChE), metal ions, Beta Amyloid Peptide (β-AP), monoamine oxidase (MAO), free radicals, tau protein, N-methyl-D-aspartate (NMDA) receptor and other related targets (Casal et al., 2002; Sambamurti et al., 2011). Here, ACHE is linked to Alzheimer disease.