More precisely, 7 (HGF, CCND1, GADD45A, DUSP4, NDNF, BTBD3 and ST3GAL6) and 3 (CD81, CD27 and PTPRC) of the 28 genes were found upregulated and downregulated respectively in patients with premalignant plasma cell disorders compared to healthy individuals. The gene discussed is CCND1; the disease is plasma cell neoplasm.