While several PHGDH inhibitors have been reported in the literature (25, 26), many of them lacked anti-proliferative activity in our AML model (data not shown), except for BI4916, a nicotinamide adenine dinucleotide (NADH/NAD+) competitive small molecule inhibitor of PHGDH (32). Here, PHGDH is linked to acute myeloid leukemia.