Taken into account the pan-sensitivity of all AML cell lines as well as the prevalence of FLT3 and DNMT3A mutations in AML, we selected MOLM-14 (FLT3-ITD mutated) and U937 (DNMT3A mutated) human AML cell lines to be used in further studies due to their representative profiles. The gene discussed is DNMT3A; the disease is acute myeloid leukemia.