Canonical markers were used to annotate the different cell types: osteoblasts (RUNX2+,COL1A1+,CDH11+,IBSP+), proliferating cells (TOP2A+,MKI67+), MSCs (SFRP2+,MME+,THY1+,CXCL12+), osteoclasts (ACP5+,CTSK+), myeloid cells (CD14+,CD74+,FCGR3A+), endothelial cells (PECAM1+,VWF+), tumor infiltrating lymphocytes (TILs; CD3D+,NKG7+), and pericytes (RGS5+,ACTA2+) (Figure 1C). This evidence concerns the gene TOP2A and neoplasm.