Among them, PI3K/AKT/mTOR pathway regulates the invasion and metastasis process of melanoma upon activation by Piezo1, and the expression of EMT-related genes and invasion and metastasis-related genes (MMP2 and MMP9) in cells changes with the alteration of Piezo1 expression (Zhang S. et al., 2022). The gene discussed is PIEZO1; the disease is melanoma.