PIEZO1 and Familial prostate cancer: Moreover, the activation of Piezo1 in prostate cancer amplifies the death-induced signal on the apoptosis pathway mediated by TNF-related apoptosis-inducing ligand (TRAIL) via Ca2+, leading to mitochondrial outer membrane permeability and mitochondrial dysfunction, and improving the therapeutic effect of TRAIL through the intrinsic apoptosis pathway (Hope et al., 2019).