Moreover, the activation of Piezo1 in prostate cancer amplifies the death-induced signal on the apoptosis pathway mediated by TNF-related apoptosis-inducing ligand (TRAIL) via Ca2+, leading to mitochondrial outer membrane permeability and mitochondrial dysfunction, and improving the therapeutic effect of TRAIL through the intrinsic apoptosis pathway (Hope et al., 2019). Here, TNFSF10 is linked to Familial prostate cancer.