IL1B and intervertebral disk degenerative disorder: Subsequently, caspase-1 converts pre-IL-1β to IL-1β, and accelerates the production and maturation of IL-1β, thereby leading to the production and development of IDD through pathways such as promoting extracellular matrix degradation, inducing inflammatory cascade reactions, promoting angiogenesis and new nerve innervation, and inducing apoptosis of nucleus pulposus cells (Sun Y. et al., 2020).