PIEZO1 and atherosclerosis: In the occurrence and development of atherosclerosis, when endothelial cells are naturally exposed to interfering and atherogenic blood flow, they will activate endothelial Piezo1, leading to calcium ion influx, and then control the blood flow induced ATP release and subsequent activation of the P2Y2/G protein alpha subunits Galphaq and Galpha11 (Gq/G11) by activating pannexin channels, and then promote endothelial cell NF-κB activation through the mediation of integrin α5β1.