Many studies have found that Piezo1 not only exerts an influence on regulating macrophage function and polarization in response to various stimuli, such as inflammatory responses and mechanical stimuli (Tang et al., 2023), but is also widely involved in macrophage-mediated inflammatory diseases, such as pneumonia (Wang L. et al., 2020), atherosclerosis (Lin C. et al., 2022), atherosclerosis (Lin C. et al., 2022) and osteoarthritis (Evans et al., 2018; Jebari-Benslaiman et al., 2022). This evidence concerns the gene PIEZO1 and atherosclerosis.