The mechanosensitive Piezo1 channel is functionally expressed in microglia, and the Piezo1 channel activates and inhibits the NF-κB inflammatory signaling pathway by initiating intracellular Ca2+ signaling, thereby down-regulating the proinflammatory function of microglia, especially the production of TNF-α and IL-6, and then it can delay the development of brain aging, central nervous system damage, and neurodegenerative diseases (Malko et al., 2023). This evidence concerns the gene PIEZO1 and neurodegenerative disease.