Yoda1-induced Piezo1 activation increases intracellular calcium levels through extracellular calcium inward flow and release of calcium from endoplasmic reticulum storage, and upregulates the activity of a series of downstream effectors including PKA, ERK, Rac1 and ROCK, leading to cytosolic ruffling and thus promoting cancer cell migration (Kim HS. Here, RAC1 is linked to cancer.