Previous studies have speculated that it can promote tumor development through the following three pathways: Releasing reactive oxygen species leads to DNA damage and gene mutations (Huber et al., 2004; Liou and Storz, 2010); controlling Epithelial-Mesenchymal transition (EMT) and metastasis to promote cancer progression; upregulation of vascular endothelial growth factor and its receptors to control tumor angiogenesis (Xie et al., 2010). Here, VEGFA is linked to neoplasm.