PIEZO1 and neoplasm: In addition, the downregulation of Piezo1 induces apoptosis of ESCCs through the 3-axis of Piezo1-P53-BAx-caspase, and the downregulation of Piezo1 inhibits the development (Gao et al., 2021), perhaps this can become a new pathway for the application of Piezo1 inhibitors in tumor treatment.