Furthermore, Piezo1 activation in periosteal stem cells also upregulates angiogenic factors such as bone morphogenetic protein-2 (BMP-2) and VEGF-A through the YAP/β-catenin signaling pathway (Liu et al., 2022); however, whether this Piezo1/YAP/β-catenin signaling axis also exists in tumor cells still needs further investigation. Here, VEGFA is linked to neoplasm.