Based on these data, OncotypeDX is recommended for HR positive and HER2 normal BC [pT1b, pN0 grade 2-3 or with lymphovascular invasion (LVI); pT1c-3, pN0; pT1-3, and pN1] according to the National Comprehensive Cancer Network (NCCN) BC Guideline Version 1.2024 [10]. The gene discussed is HR; the disease is breast cancer.