In addition, activated platelets in platelet-rich fibrin patches produce soluble CD40 ligand (sCD40L), which inhibits the infiltration of CD4+CD25+Foxp3+ regulatory T cells (Tregs) into the microenvironment of glioblastomas, and plays an important role in suppressing antitumor immunity (Panek et al., 2019). This evidence concerns the gene CD40LG and glioblastoma.