However, all patients with fornix metastases also had supratentorial and infratentorial multiple metastatic lesions, and other organ and system metastases were detected. When metastatic lesions were evaluated completely, estrogen receptor positivity and progesterone receptor positivity were found with fornix metastasis in all patients with breast cancer, except for one medical record that could not be accessed. The gene discussed is ESR1; the disease is breast cancer.