In addition, the expressed P-selectin glycoprotein ligand-1 (PSGL-1), L-selectin, lymphocyte function-associated antigen 1 (LFA-1), integrin, or very late antigen-4 (VLA-4) on the WBCMs increase their cell adhesion with the surface receptors of cancer cells and hence achieving active targeting function (Wu et al., 2022; Chen et al., 2023). The gene discussed is SELPLG; the disease is cancer.