In this study, MNX1 mRNA was mildly decreased in ALS motor neurons (SMD = −0.82, p = 0.103, FDR = 0.377), but the nearest neighbor distance between MNX1 motifs and ALS-increased genes was decreased by 25% relative to other genes (Figure 5A). The gene discussed is MNX1; the disease is amyotrophic lateral sclerosis.