Other annotations most strongly enriched with respect to ALS-increased genes included extracellular matrix structural constituent (e.g., LAMA2, TGFBI, FN1), TYROBP causal network in microglia (e.g., NCKAP1L, APBB1IP, TYROBP), and spinal cord injury (e.g., AQP1, VCAN, AIF1) (Supplementary Excel file S1). Here, TYROBP is linked to amyotrophic lateral sclerosis.