Likewise, ALS-decreased DEGs with decreased expression in endstage G93A motor neurons from both strains included PRUNE2, HTR7 and USP13 (Supplementary Figure S25B) and such genes were associated with generation of neurons, neuron development and cell projection morphogenesis (Supplementary Figure S25D). The gene discussed is PRUNE2; the disease is amyotrophic lateral sclerosis.