SRGN and amyotrophic lateral sclerosis: Matrisome genes significantly elevated in ALS samples include COL12A1 (collagen), C1QB (ECM-affiliated), LAMA2 (ECM glycoprotein), SERPINA3 (ECM-regulator), SRGN (proteoglycan) and CCL2 (secreted factor) (Supplementary Figures S19H–M).