Based on RNAInter database annotations (Kang et al., 2022), ALS-increased DEG mRNAs frequently interacted with RNA-binding proteins such as CELF5, CPEB1 and PABPC5 (p < 0.001, FDR = 1.00, Fisher’s exact test; Supplementary Figure S16A). Here, CPEB1 is linked to amyotrophic lateral sclerosis.