Overall, 62% of ALS-decreased DEGs had FUS-interacting mRNAs (e.g., USP13, ECEL1, SPA17) as compared to 54% of non-DEGs (p = 0.004, FDR = 0.915, Fisher’s exact test; Supplementary Figures S16B, F). Here, USP13 is linked to amyotrophic lateral sclerosis.