Among ALS-increased DEGs, those with TSS nearest to a putative MNX1 binding site (e.g., MLC1, ANGPT1, ERBB4) tended to be more strongly upregulated during motor neuron differentiation (rs = −0.21, p = 0.0055) (Supplementary Figure S23H). Here, ANGPT1 is linked to amyotrophic lateral sclerosis.