In mice bearing control tumors (with control vector and NonSil hairpin), extensive metastasis to the lungs, liver and bones was observed in the absence of BMP4, as evidenced by in vivo imaging of tumor-specific luciferase activity (Fig. 3a), ex vivo imaging of TurboGFP-tagged metastatic lesions (Fig. 3b) and qPCR quantification of tumor-specific TurboGfp DNA in different organs (Fig. 3c). Here, BMP4 is linked to neoplasm.