A central role for IL-6 in promoting peritoneal carcinomatosis has been inferred from research consistently demonstrating elevated levels of IL-6 in the serum and ascites of patients with PC compared to those without it, in ovarian [105, 106], colorectal [107–109], gastric [110] and other cancers [17, 111–113]. Here, IL6 is linked to pachyonychia congenita.