KCNK1 and neoplasm: Further, TME was assessed as a whole, and we found that KCNK1 expression was significantly negatively correlated with TME stromal score (r = − 0.22; p = 7.3e-6), immune score (r = − 0.17; p = 5.3e-4) and ESTIMATE score (r = − 0.21; p = 2.1e-5), and positively correlated with tumour purity (r = 0.22; p = 3.9e-6) (Fig. 9D).